The European qualifying competition begins in March, with 13 countries from the continent going through to the 32-team finals.
There will be three rounds of fixtures in March, three more in September, and two each in October and November.
That will only increase pressure on a fixture calendar that is already packed, especially with the postponed Euro 2020 set to go ahead in June and July.
That means a team that reaches the final of Euro 2020 can expect to play 17 competitive games between March and November next year.
Only the winners of the 10 groups will qualify automatically for the finals, which are to take place in November and December of 2022.
The 10 runners-up will go into play-offs alongside the two best Nations League group winners who miss out on qualifying via the traditional path.
Those play-offs, in March 2022, will produce three more qualifiers in total.
Germany, whose coach Joachim Loew has been under severe pressure after poor recent results for the 2014 World Cup winners, will be expected to come through a group in which Romania and Iceland appear their main threats.
Reigning European champions Portugal’s main opposition will come from Serbia and the Republic of Ireland in Group A. Cristiano Ronaldo will be 37 by the time the finals come around.
Spain notably drew Sweden and Greece in Group B, while Italy must take on Switzerland in Group C.
Belgium, the world’s top-ranked team, will meet Wales. The sides met in the Euro 2016 quarter-finals with Wales coming out on top.
“We are not going to complain about the draw,” said Belgium coach Roberto Martinez.
“It will also be an emotional reunion for me because it was in Wales, at Swansea, where I started my coaching career in 2007.”
After qualifying for Euro 2020 to reach their first major tournament since the 1998 World Cup, Scotland was handed just about as kind a draw as possible on the road to 2022 as they were placed in Group F with Denmark and Austria.
“We have to be happy with the draw but very, very wary that it will be a dangerous draw as well,” said Scotland manager Steve Clarke, whose side also face familiar foe Israel, the Faroe Islands, and Moldova.
World Cup qualifying has already started elsewhere.
There will be four direct qualifiers from Asia to join hosts Qatar, four from South America, while Africa has five qualifiers.
Three teams will progress from the North, Central America, and Caribbean zone, with the remaining two berths awarded to the winners of intercontinental play-offs in June 2022.
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