Giovanni Di Lorenzo, Andre-Franck Zambo Anguissa, Hirving Lozano and Lorenzo Insigne could all miss the Europa League second leg against Barcelona.
The four key Napoli players are currently injured. All of them, except for Lozano, took part in the first match against Barca.
Stanislav Lobotka and Matteo Politano, who are more of back-up players, are also unavailable.
The first leg finished in a 1-1 draw.
Napoli take on Barcelona on Thursday, February 24, at 21:00 CET. There is no away-goal rule in European competitions.
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